Nattokinase and Vitamin K2: Should You Take Them Together?
, 4 min reading time
A plain-English guide to vitamin K2 with nattokinase and nattokinase with serrapeptase: what each combination contains, how they differ and who should be cautious.
Last reviewed: October 2026
Vitamin K2 with nattokinase is one of the most common combination formulas, and nattokinase with serrapeptase is another. Both turn up in the same searches, but they contain different ingredients and suit different shoppers. This guide explains what each combination is, how to compare products, and who should speak to a doctor first. It is general information, not medical advice. For the basics, see our Nattokinase Benefits, Dosage & Side Effects Guide.
Why Are Vitamin K2 and Nattokinase Sold Together?
Both ingredients are linked to natto, the Japanese food made from fermented soybeans. Nattokinase is an enzyme produced during natto fermentation, and menaquinone-7 (MK-7), a form of vitamin K2, is commonly sourced from natto as well. Some brands combine the two in one capsule or softgel for convenience, so you don't need to buy two supplements.
Human research on nattokinase is still developing, and neither ingredient should be considered a treatment for any medical condition.
What Is MK-7?
Vitamin K2 comes in several forms. MK-7 (menaquinone-7) is the form most often used in supplements and is usually expressed in micrograms (mcg). Vitamin K is involved in how the body activates proteins related to blood clotting and bone, which is why K2 products are usually positioned around bone and cardiovascular wellness.
Vitamin K2 With Nattokinase Products Compared
The two products below look similar but are built differently. One is nattokinase-led and one is K2-led, so compare the label amounts rather than the product name.
| Product | Vitamin K2 (MK-7) | Nattokinase | Format and size | Price (AUD) |
|---|---|---|---|---|
| Swanson Vitamin K2 with Nattokinase | 50 mcg | 100 mg, 2,000 FU | Softgel, 30 count | $43.95 |
| Vitacost Vitamin K2 MK-7 with Nattokinase | 100 mcg | 16 mg, 320 FU | Softgel, 90 or 200 count | from $23.95 |
If nattokinase strength is your priority, the Swanson formula provides a full 2,000 FU. If vitamin K2 is your priority, the Vitacost formula has the higher K2 dose, with nattokinase as a smaller addition. Both softgels contain gelatine, so they are not suitable for vegetarians or vegans, and both involve soy-derived ingredients.
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Sale -20%
Dr. Murray's
Dr. Murray's Nattokinase, 2,000 FU
FAST 24HR DISPATCH
$22.51 - $34.43
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Arthur Andrew Medical
Arthur Andrew Medical Nattovena, Pure Nattokinase, 4,000 FU
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$37.92 - $129.82
Sale -12%
Micro Ingredients
Micro Ingredients Nattokinase, 240 Enteric Coated Softgels, 4,000 FU
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$85.92
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Eumundi Botanicals
Nattokinase Natural Soy Enzyme, 2,000 FU
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$39.95
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Micro Ingredients
Micro Ingredients, Nattokinase, 240 Vegetarian Capsules
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$79.95
Sale -12%
Doctor's Best
Doctor's Best CoQ10 + Nattokinase, 60 Veggie Caps, 2,000 FU
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$52.94
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NOW Foods
NOW Foods Nattokinase, 100 mg, 2,000 FU
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$51.30 - $85.38
Swanson Vitamins
Swanson Vitamin K2 with Nattokinase, 30 Softgels, 2,000 FU
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$43.95
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Source Naturals
Source Naturals NSK-SD, Nattokinase, 200 mg, 4,000 FU, 30 Vegan Capsules
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$64.18
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CATALO
CATALO Extra CoQ10, Heart Formula with Nattokinase & Flaxseed Oil, 30 Softgels, 20,000 FU/g
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$107.70
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Nutricost
Nutricost Nattokinase, 100 mg (2,000 FU), 120 Capsules
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$38.56
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ProHealth Longevity
ProHealth Longevity, Nattokinase Pro 2000, 60 Capsules
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$99.95
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Vitamatic
Vitamatic, Nattokinase, 120 DRcaps® (100 mg per Capsule)
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$39.95
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Allergy Research Group
Allergy Research Group, Nattokinase, 100 mg, 60 Softgels
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$114.95
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Probase Nutrition
Probase Nutrition, Nattokinase, 120 Capsules (100 mg per Capsule)
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$69.95
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Vitacost
Vitacost, Mega Nattokinase, 20 mg (2,000 FU), 90 Capsules
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$49.95
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Vitacost
Vitacost, Nattokinase NSK-SD, 2,000 FU, 90 Capsules
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$59.95
Nattokinase With Serrapeptase: A Different Combination
Serrapeptase is another proteolytic enzyme. Combination products pair it with nattokinase for shoppers who want both enzymes in one capsule. Two options in our range:
- Doctor's Best Natto-Serra: 2,000 FU nattokinase with 40,000 SPU serrapeptase in a once-daily delayed-release vegan capsule, 90 capsules, $75.95.
- Solaray Nattokinase Serrapeptase: 3,000 FU nattokinase with 60,000 units serrapeptase in an enteric-coated VegCap, 30 capsules, $72.66.
Compare the labelled activity of each enzyme, the capsule type and the serving size. Both products contain soy.
Which Combination Is Right for You?
- You mainly want nattokinase: a standalone product gives you the most control. See our best nattokinase supplements in Australia picks.
- You specifically want K2 and nattokinase in one softgel: compare the Swanson and Vitacost formulas above.
- You want both enzymes: compare Natto-Serra and Solaray's nattokinase serrapeptase formula.
Who Should Be Cautious?
Check with your doctor or pharmacist before using either combination if any of these apply:
- You take blood-thinning medication. Nattokinase has fibrinolytic activity and may increase bleeding risk. Vitamin K also plays a role in blood clotting and can interact with warfarin. Product labels advise speaking to your doctor first if you take blood thinners.
- You have a bleeding disorder, are pregnant or breastfeeding, or have surgery planned.
- You have a soy allergy. Nattokinase and natto-derived K2 come from fermented soybeans.
- You avoid animal-derived ingredients. The Swanson and Vitacost softgels contain gelatine.
Frequently Asked Questions
Can I take vitamin K2 with nattokinase?
Many products combine them, and each product's label gives its own directions. If you take blood thinners or have a health condition, speak with your doctor or pharmacist before using either ingredient.
Does nattokinase contain vitamin K2?
No. Nattokinase is an enzyme and vitamin K2 is a vitamin, though both are linked to natto. A product only contains K2 if it is listed on the label, as in the combination formulas above.
What is the difference between nattokinase and serrapeptase?
Both are proteolytic enzymes, but they come from different sources. Nattokinase comes from fermented soybeans (natto), while serrapeptase is produced by a bacterium. Some products combine the two.
Is it better to buy a combination or separate products?
A combination is simpler. Separate products let you choose each ingredient's amount. Compare labelled amounts either way, and see our nattokinase supplements collection for the full range.
Where can I buy nattokinase with K2 in Australia?
Both K2 formulas above are available from Wallaby Wellness and ship Australia-wide. See our guide to where to buy nattokinase in Australia for other options.
